When you track that many symbols, it is likely you are doing scanning, and/or real-time breadth analytics. Thus, you can exhaust the available RAM in your computer easily.
Check the Task Manager to see if your computer is running low on RAM. If so then consider adding RAM to your computer may help.
If you find that your computer is consistently using 100% CPU, then you may need a faster CPU with multiple cores to improve the overall performance.
A possible cause of this problem can be a mistake in your NeoTicker settings. Check the Cache Manager> RAM Cache tab; click on the option button to bring up the RAM Cache Options window. Under the Smart Tool tab, if it is set to auto, change that to Disable to lower the spike in RAM usage.